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Expert Content LibraryIntro To BFS

Chapter 24: CapEx and Fixed Costs

As compared to more traditional filling processes such as glass vials, Blow-Fill-Seal typically has noticeably lower upfront capital requirements.

This is largely due to a smaller floor space requirement, as well as a streamlined fill and finish process that does not require significant support stations such as depyrogenation tunnels on the vial infeed or stoppering and capping stations.

BFS can also have lower fixed operating costs than other traditional formats. BFS typically requires little to no human intervention, which results in fewer line operators.

Likewise, cost requirements for ongoing storage of raw materials are comparatively low. That’s because pharmaceutical-grade resin is relatively inexpensive to store and does not require a cleaning process prior to use.

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