Blow-Fill-Seal is an aseptic drug packaging process that has existed for more than 50 years. The plastic containers that BFS forms, fills, and seals are typically used for ophthalmic or inhalation administration of the drug.
BFS containers have also been used as alternatives to glass vials for injection administration, whether by pushing a syringe into the BFS container to withdraw the dose, or by affixing a luer lock onto the end of the BFS container for direct injection to the patient or IV bag.
ApiJect has reimagined how to use BFS by thinking of the plastic container as an interconnecting component of a larger drug delivery system.
Our design approach is to enable users to attach non-BFS components to the BFS container. This can allow for easy administration of the drug product from a single prefilled device – whether that be parenteral, nasal, or any other administrative route.
A simple application of our design approach can be seen in our first drug delivery system for intramuscular 0.5mL injections.
We bring together a pen needle-style hub with a BFS container to create a new type of prefilled parenteral. This drug delivery system is designed to have the benefits of a prefilled syringe but with better manufacturing scale, supply chain simplicity, and cost efficiencies.
By bringing together BFS and attachable plastic components in simple, effective ways, ApiJect is unlocking the potential for BFS to serve as the central core element for single-dose, prefilled, drug delivery systems.